mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells
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چکیده
منابع مشابه
mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells.
The myelination of axons in peripheral nerves requires precisely coordinated proliferation and differentiation of Schwann cells (SCs). We found that the activity of the mechanistic target of rapamycin complex 1 (mTORC1), a key signaling hub for the regulation of cellular growth and proliferation, is progressively extinguished as SCs differentiate during nerve development. To study the effects o...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1620761114